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In attempting to understand whether manipulation of NEP24.11 to prevent the degradation of GLP-1 into GLP-1(2836) would affect the clinically observed cardioprotective actions of GLP-1, we found that the in vitro cAMP response to GLP-1 was lost with addition of the NEP24.11 inhibitor sacubitril

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Total brain APP and A oligomer levels are reduced in Liraglutide-treated AD mice (147, 158160), and intervention with liraglutide can prevent tau hyperphosphorylation (161164)