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Figure 2 The core characteristics and mechanisms of candidalysin are well-defined: it exerts cytotoxicity by membrane insertion/lytication, activates pathways such as EGFR-MAPK and NLRP3 inflammasome to induce inflammation and damage in host cells, and targeted anti-infection strategies against this toxin have been summarized (Lortal et al., 2025)

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Nat Rev Mol Cell Biol 15:482496 Nacarelli T, Liu P, Zhang R (2017) Epigenetic basis of cellular senescence and its implications in aging

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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 1289 million children, adolescents, and adults (in Eng)

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