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[3] With disease progression, patients may experience fear, anxiety and depression and psychological counseling should therefore be considered

This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment

10.1017/S0007114513000068 68 MikusN.MarszaekK.PodlachaM.IqbalA.PuchalskiC.wiergielA

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