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Ethical Concerns: Diverting from evidence-based treatments can lead to worsening health conditions and missed opportunities for proper care

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Observational studies among patients with type 2 diabetes have shown that the GLP-1 receptor agonist-SGLT-2 inhibitor combination results in more significant improvements in haemoglobin A 1c and blood pressure while lowering body weight than either drug class alone.121314151617 However, these represent surrogate outcomes, and whether this combination is associated with a reduced risk of macrovascular and microvascular complications remains unclear