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At 1227 PM EDT, severe thunderstorms capable of producing waterspouts were located along a line extending from 11 nm west of Niagara River to 14 nm southwest of Lewiston, moving northeast at 30 knots

Kim MS, Kim JY, Song YS, et al

9 , R61 (2007)

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For context, the concentrations required to activate intracellular cascades such as PI3K/Akt, upregulate BDNF, or stimulate autophagy in neuronal tissue are derived from preclinical studies that used substantially higher relative exposures than those achievable in the human brain at therapeutic doses