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Sorafenib upregulates ABCC5 via the PI3K/Akt/Nrf2 pathway, which inhibits lipid peroxidation-mediated ferroptosis and promotes cancer growth, resulting in acquired sorafenib resistance in human HCC cells, according to Huang et al (91)
Moosavi M et al
Those using GLP-1s had a significantly reduced risk of cataracts compared to those using other weight-loss drugs or no pharmacological treatment: Relative Risk for Cataract by Medication Status The greatest reductions were seen in cortical and posterior subcapsular cataracts, according to the study
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