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When melanin is overproduced or unevenly distributed, visible darkened areas can develop, presenting as hyperpigmentation or patchy tone

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One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications

The relevant OD value at 450nm for stopping the staining is between 2.0 - 2.5