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TABLE 1 Summary of case reports of GLP-1 receptor agonists-induced acute pancreatitis reported in the literature

According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

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These strategies effectively enhance both water retention and thermal resilience

Lower-dose versions of these same active ingredients, known respectively as Victoza and Ozempic, have been used for years to help people with diabetes control their blood sugar levels