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Weeks 12: 2 mg once weekly Weeks 36: 4 mg once weekly Weeks 710: 8 mg once weekly Week 11+: 12 mg once weekly (if tolerated) Fast escalation: Select cases, monitored closely This fast-escalation schedule is used only in specific situations where close supervision is available, such as in specialty clinics or structured clinical trial settings that follow strict safety protocols

Therefore, it is suggested that GLP-1RAs are optimal anti-diabetic medicines for T2D patients with normal BMI, being successful in both reducing glucose levels and maintaining a stable body weight

Individual preference determines which approach fits better into specific lifestyles

The human evidence is early and thin compared with naltrexone's mountain of trials