Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Acknowledgments The authors would like to thank the other employees of Falsified Medicines and Medical Devices Department of National Medicines Institute for their assistance with preparing photographic documentation of samples and preparing samples for analysis
Protect from light, avoid freeze-thaw cycles on reconstituted solution, and inspect the vial for clarity and absence of particles before each draw
Always talk to your doctor about the risks and benefits of any treatment
Offers finer control than 100-unit