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Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

462 The most advanced application of POCs is the delivery of charge-neutral oligonucleotides, such as PNA and PMO, using CPPs

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In vitro GSH sensitivity and selectivity experiments The HT adducts were prepared by combining the HT protein (~50 M in PBS) with the respective TRaQ-G ligand (1.52 excess, stock solution 50 mM in DMSO) and rotating the resulting solution for 1 h at 20 C