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GHK-Cu is a copper-complexed tripeptide with the amino acid sequence glycyl-histidyl-lysine (GHK)

The SURMOUNT-5 trial, published in the New England Journal of Medicine in 2025, randomly assigned 751 adults with obesity to either tirzepatide or semaglutide for 72 weeks.[1] The results were clear: Average weight loss with tirzepatide: 20.2% Average weight loss with semaglutide: 13.7% Tirzepatide patients were also more likely to hit major milestones 10%, 15%, 20%, and even 25% body weight loss

Promising findings from clinical trials indicate that this medication may possess substantial potential for promoting weight loss

Patients should also report diarrhea that significantly impacts quality of life or prevents maintaining adequate nutrition and hydration