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Intermuscular adipose tissue-derived inflammatory adipokines, exacerbated by aging, obesity, and sedentary behavior, promote both fat accumulation and chronic inflammation within skeletal muscle, driving adipogenic differentiation at the expense of myogenesis and thereby contributing to reduced muscle quality and increased metabolic risk [81]

PMID: 41903965 Jiang L et al

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All authors drafted the manuscript, participated in data analyses and interpretation, and revisions of the manuscript and approved the final version

Furthermore, these insights underscore the importance of host-microbiome interactions for cardiovascular health and highlight the potential for targeted dietary interventions to mitigate disease risk