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It is worth noting that the weight loss and metabolic improvements achieved with GLP-1 agonists may actually reduce overall thrombotic risk over time by addressing several modifiable risk factors

21. Edo GI et al

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Request the following labs before starting and then at 3 and 6 months: Total testosterone (optimal: 500 to 900 ng/dL for most men) Free testosterone (optimal: 15 to 25 pg/mL) Estradiol (optimal: 20 to 40 pg/mL) SHBG (reference: 10 to 57 nmol/L) LH and FSH (reference: LH 1.8 to 8.6 mIU/mL, FSH 1.5 to 12.4 mIU/mL) If testosterone is rising and estradiol is falling over time, the trajectory is positive regardless of how you feel in the short term