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Stabler 24 Patients with severe abnormalities should receive injections of 1000 g at least several times per week for 1 to 2 weeks, then weekly until clear improvement is shown, followed by monthly injections

However, it should not replace a proper diagnosis, imaging, physical therapy, rehabilitation, or other medically recommended treatment

Schedule shape Typical published research planning splits a daily total into one or two doses

Because it lacks this fundamental human testing, the FDA considers it an experimental compound with unknown long-term risks, preventing it from being approved as a legal medical treatment

Clinical Principle The clinical diagnosis of IC/BPS requires a careful history, physical examination, and laboratory examination to document basic symptoms that characterize the disorder and exclude infections and other disorders (see Figure 1: IC/BPS Diagnostic and Treatment Algorithm)