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PIONEER 1 compared oral semaglutide with placebo [76], while PIONEER 24 compared oral semaglutide with the SGLT2i empagliflozin (25 mg once daily), the DPP-4 inhibitor sitagliptin (100 mg once daily), and the subcutaneous GLP-1RA liraglutide (1.8 mg once daily) [38, 39, 61, 62]

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