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The addition of glucagon receptor agonism raises theoretical considerations around heart rate elevation , and Phase 2 data did show modest increases in resting heart rate in some participants a finding that will require careful monitoring in Phase 3 cardiovascular outcome trials

The yeast cell biomass was obtained by centrifugation of culture medium (3000 g , 10 min, + 4 C, Centrifuge 5804R Eppendorf, Germany) containing potato wastewater enriched with glycerol

However, for long-term storage (months or years), you should store the lyophilized vials in a freezer, ideally below -20C

USA 92 , 1028710291 (1995)

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