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In light of the promising evidence regarding the beneficial effects of GLP-1 RAs in glycemic control and weight reduction, their use in diabetic and obese patients, respectively, has increased substantially

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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

In contrast, participants who were given five weekly sodium hylauronate treatments and no semaglutide saw no significant change