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Yes, B12 can expire
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
The evidence reality This is the section that the marketing around AOD-9604 tends to skip
Under appropriate medical supervision, IV hydration can help restore fluids and electrolytes for individuals who are significantly dehydrated or unable to maintain adequate hydration orally
These results indicate that 3-AR is required for the anabolic effects of these treatments on body weight [2]
