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As indicated in a meta-analysis of MTHFR consisted of 7 studies, individuals carried with TT homozygotes had the greatest risk of schizophrenia, compared to the subjects with CC wild type and CT heterozygous genotypes 44

However, some prescribers use microdosing for patients who are highly sensitive to GLP-1 agonists, have had severe side effects at standard starting doses, or want to test tolerance before committing to a full protocol

GLP-1 receptor agonists slow gastric emptying and activate satiety signals in the brain, dramatically reducing hunger

Even the recommended dose of 4 g/day for two weeks can elevate liver enzymes like ALT to three times the normal limit in about one-third of patients 59