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Reduced level of glutamate has been reported in PFC of mice in different models of depression such as chronic unpredictable mild stress (CUMS) (66), chronic social defeat stress (CSDS) (112, 116), and chronic forced swim stress (CFSS) (122)

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Furthermore, additional data from 1567 subjects with the same measures of depression and metabolites repeated at 6-year follow-up (20102013) were used in a secondary analysis

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Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)