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27 In vitro activation of the GLP-1R by exendin-4 enhanced osteogenic differentiation while inhibiting adipogenic differentiation of BMSCs
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In one phase 3 clinical trial , participants taking 5 mg of tirzepatide weekly lost an average of 15% of their body weight after 72 weeks
Despite the differences in the nature of the development of these pathologies, both diseases are accompanied by gut dysbiosis ( -/- mice show better glucose tolerance and increased gut A
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