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SGLT2 Inhibitors (e.g., Empagliflozin, Canagliflozin) SGLT2 inhibitors work by blocking the sodium-glucose co-transporter 2 in the kidneys, preventing glucose from being reabsorbed and allowing it to be excreted through urine
At a 4mg/mL concentration (10mg vial in 2.5mL BAC water), a 12mg weekly dose requires a 3mL injection volume which exceeds the practical limit for a single subcutaneous injection into most sites
1A, 2A)
It also appears to modulate irisin expression in muscle cells
Most patients begin noticing appetite suppression and reduced hunger within the first 12 weeks of starting GLP-1 therapy
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