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Note: Tirzepatide has a slightly shorter half-life than semaglutide, which is why some patients feel the effects wear off even faster at the end of the week
Similarly, studies on DPP-4is have found neutral effects on fracture risk (2325)
Lets look a bit deeper into the differences between 503A vs 503B
When performing an intention-to-treat analysis, the HR for MOF was found to be 0.89 [0.781.02] with GLP-1 RAs compared to DPP-4is, although this became significant in the fully adjusted model (HR 0.85 [0.74 0.98])
For example, shots given into the muscle are often needed less often than those given under the skin
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