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Apr 26 2019;11(5)doi:10.3390/nu11050962 Boniol M, Franchi M, Bota M, et al
MS analysis was carried out in both positive and negative ion modes via electrospray ionization, with full-scan detection covering m/z 751000 at a resolution of 35,000
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the metabolite identifiers, associated metabolic pathways, effect size (d-value), t-test ( p -value), FDR corrected p -value 47 and the mean normalized metabolite abundance of both populations
Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
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