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Thats the mechanism behind reduced appetite, but it also explains most of the side effects people struggle with
Emerging DPP-4 inhibitors: Focus on saxagliptin for type 2 diabetes
Glucagon receptor agonism increases resting energy expenditure and shifts hepatic lipid metabolism
In contrast, truncation of the first two residues of exendin-4 does not significantly alter its affinity but does lower potency for cAMP signalling by ~200-fold 23,24,25
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