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J Clin Invest 2014;124:4473-88.ArticlePubMedPMC 58

J.SajediA.SmithK

The incidence decreased over time as patients developed tolerance, with most nausea episodes occurring during dose escalation periods

Medication Age Eligibility and Dosing Framework for Young Patients Eligibility extends beyond age alone

In addition, as with any emerging pharmacology, careful and continued analysis for potential adverse effects is required, especially as these therapies advance for treatments in genetically diverse patient populations