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On the other hand, the re-remethylation block hypothesis argues the opposite, that decreases in are responsible for increased Hcy, and presumably GSH
Another advantage is its gentle nature
Figure EV6 Metabolic characterization of A549shNRF2-/H460shNRF2-BIND rescue cell models
Conversely, a more recent 16-week randomized controlled trial ( n = 58) reported that sulforaphane (approximately 45 mg/day) failed to change the severity of psychotic symptoms compared to placebo using the total Positive and Negative Syndrome Scale (McGuinness and Kim, 2020)
