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In the case of MS, while axonal and neuronal destruction is the ultimate fate and cause of disability in disease, glia is present in inflammation (microglia), myelin loss and tentative regeneration (oligodendrocyte) and synaptopathy itself (astrocytes)

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Discussion In the present study, we demonstrated that permanent IGF-1 attenuated oxidative SIPS of hepatocytes via inhibiting the interaction between nuclear p53 with progerin (Fig

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