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Exposing transdermal patches to external heat sources (heating pads, saunas, hot tubs, prolonged sun exposure) can significantly increase drug absorption and potentially cause overdose

Demulcents are effective in treating diarrhea, constipation and inflammatory conditions of the gastrointestinal tract

This is not a gap in medical knowledge so much as a reflection of how rapidly GLP-1 adoption has outpaced formal guideline development

In addition, physicians should keep in mind that most of the reproductive benefits observed are likely indirect and that GLP-1s have not been evaluated as treatments for male infertility or hypogonadism