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Endoplasmic Reticulum stress leads to protein misfolding and activation of the unfolded protein response (UPR), which promotes ROS generation, influencing cell survival and drug resistance [73]

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In some blastocysts, we observed degenerated blastomers, where the enzyme in the cytoplasm was arranged in larger clusters or had a homogeneous localization

Sardu C, Modugno P, Castellano G, Scisciola L, Barbieri M, Petrella L, Fanelli M, Macchia G, Caradonna E, Massetti M et al