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Those constraints narrow how far the results extend to higher-risk patients

[1] Persistently high B12 levels warrant medical investigation, as they may signal liver disease, kidney dysfunction, or certain haematological disorders

Research literature suggests that this axis is not governed by linear onoff signaling, but rather by pulsatile, context-sensitive interactions shaped by feedback loops and receptor specificity

And even people who interrupted treatment for just six months before resuming saw their cardiovascular benefit reduced from 18% to approximately 12%, a gap that never fully closed

Many people resume light activities after about a week, but full recovery and final outcomes can take longer