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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies

It is located around 3650 meters above sea level on the southwest of Bolivia, which is in the Andes Mountains

However, systematic reviews and randomised controlled trials supporting these claims are notably absent from peer-reviewed literature

Some sensitive compounds may not be