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The satiety effect is additive with GLP-1 agonism because the pathways don't overlap which is why CagriSema outperforms semaglutide monotherapy and tirzepatide on some endpoints
Retatrutide monotherapy at 12 mg produced approximately 24% body weight loss compared to roughly 11% for cagrilintide 2.4 mg alone
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Yi, X., et al
Setting up pharmaceutical ingredient supply chains that adhere to the complex regulations on manufacturing and quality could take monthsor perhaps longer if the Administration were to require them be sourced in the United States rather than China
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