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doi:10.1016/S0016-5085(98)70538-3 Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA

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Target Engagement DSIP does not exhibit a clearly defined high-affinity binding profile to a single receptor system, which distinguishes it from many receptor-specific peptide ligands

They simply stop working, and the most common interpretation is that the protocol itself is not effective

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