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When B12 levels are low, symptoms like brain fog, irritability, low mood, and difficulty concentrating often follow

A deficiency in this vitamin can create a variety of symptoms

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Vitamin B-12 deficiency either indirectly makes people lose weight or gain weight