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Furthermore, escalated oxidative stress can activate GSK3 [90], contributing to elevated A levels [60] (see Section Unlocking Melatonins Anti-Amyloidogenic Potential ) and hyperphosphorylation of the microtubule-associated protein tau [91, 92] (see Melatonins Potential to Counteract Tau Pathology )

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doi: 10.1017/S0967199417000028 65

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