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This work further highlights how physiologically relevant in vitro systems are becoming a mechanistic backbone for predicting oral bioavailability, improving translational relevance, and supporting the development of next-generation therapeutics

Metallothioneins, the most important intracellular copper storage proteins, are also upregulated by GHK-Cu, providing an additional protective mechanism against copper-induced toxicity

13.3.6 Excessive immunostimulation in compromised hosts Emerging evidence indicates that probiotic administration can precipitate severe infections and other adverse events in specific patient populations

A., Breathett, K., Brouse, S., Butler, J., et al