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Furthermore, the study demonstrated that the addition of growth hormone to BPC 157-treated fibroblasts activated Janus kinase 2 (JAK2), a key downstream signaling molecule in the GH receptor pathway
Chapter 4 Tissue carbohydrate metabolism, gluconeogenesis and hormonal and environmental influences
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, at histone H3 lysine 18 lactylation [H3K18la]), thereby inducing immunosuppressive gene expression (including Arg1 ) and driving macrophage polarization toward the M2 phenotype (19)
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