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Apart from the use of oral contraceptives and/or various anti-androgenic drugs in PCOS, there is extensive literature evidence of positive effects when using specific drugs to counteract IR, such as metformin (4, 5), or when administering complementary substances, such as inositols, alpha lipoic acid, or combinations of these (6-11)
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The variance is largely explained by training status - patients who maintain structured resistance training during treatment show significantly less lean mass loss than sedentary patients
