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While heart health is a current benefit of Semaglutide, current studies show that Tirzepatide might be more effective as a weight loss medication due to its higher dosage than Semaglutide, with many patients experiencing milder side effects overall

Deficiency of Trem2 in macrophages worsens lipid accumulation and ferroptosis in TECs via IL-1-dependent CD36 upregulation, thus promoting DKD progression (201)

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