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It is a modified GHRH(1-29) analog designed to resist enzymatic breakdown and extend duration of action through albumin binding. Key features of CJC-1295 DAC CJC-1295 with DAC: Activates the GHRH receptor on pituitary somatotroph cells Stimulates endogenous GH release Increases downstream IGF-1 signaling Binds to albumin through the DAC structure Produces sustained GH/IGF-1 effects over multiple days Because of this extended exposure, CJC-1295 DAC is usually discussed in research contexts focused on longer-duration GH-axis activation rather than short GH pulses

This improved efficacy is seen in both the prediabetes and T2D populations

Do not use GLP-1 treatments if: Warnings and Precautions: Pregnancy and Reproductive Health: GLP-1 medications may cause harm to a fetus and should not be used during pregnancy or when planning to become pregnant

This system could be stimulated in the first minutes before a meal and would be involved in foraging and the cephalic phase of insulin secretion, as we have recently shown 16

References 1 Acuna-GoycoleaC.van den PolA