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A landmark 2023 study published in JAMA found that GLP-1 agonist users experienced increased risks of gastrointestinal adverse events (with gastroparesis risk elevated compared to patients using other diabetes medications), while a 2024 case report in PMC documented the strong relationship between semaglutide use and gastroparesis symptoms that resolved only after drug discontinuation
Although stopping these medications may not immediately spike blood sugar levels, it elevates the risk of hospitalization related to diabetes complications
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