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Whole-blood measurements are dominated by erythrocyte glutathione and require appropriate volume- or erythrocyte-based normalization, whereas plasma and serum contain much lower concentrations and are particularly sensitive to hemolysis and processing delay

Safety considerations BPC-157 has shown a strong safety profile in animal studies with no toxic dose identified, but dosing should always involve a physician because animal data does not translate directly, individual factors affect response, and product quality varies

A role of oxidative stress in GO is supported by a number of basic studies suggesting that ROS promote the proliferation of OFs and the release of GAGs, the synthesis and secretion of cytokines, and the expression of other factors involved in the pathogenesis of GO, namely heat shock protein 72 (HSP-72), HLA-DR and ICAM-1 ( Figure 1 In this context, a number of studies, performed both in vitro and in vivo , investigated the effects of antioxidant agents in GO, including selenium, pentoxifylline, quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin ( Oxidative Stress and Proliferation of Orbital Fibroblasts Burch et al

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