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All randomly assigned participants were to undergo a planned 72-week treatment period that included a dose-escalation period of up to 20 weeks
KAT6A occurs in a protein complex with the chromatin adaptor proteins BRPF1, BRPF2, or BRPF3, ING4 or ING5, and MEAF6 (Doyon et al, 2006)
It contributes to early satiety and weight loss, but also underlies many of the adverse effects and emergency department presentations associated with these medications
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