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Plasma exposure for oral semaglutide was shown to be dose-dependent in a multiple-dose study ( N = 84 healthy male individuals and 23 male individuals with T2D)

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They also slow digestion, keeping food in the stomach longer to support portion control

For bariatric and medical-weight-loss patients, this phenomenon is familiar

Wegovy HD 7.2 mg, the recently approved higher-dose version of semaglutide, shows a similar dose-dependent increase, with dysesthesia reported in roughly 22% of people at that dose compared to about 6% at the standard 2.4 mg dose