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This has a much greater impact on melasma clearance compared to antioxidant supplementation
Lopes J, Arnosti D, Trosko JE et al (2016) Melatonin decreases estrogen receptor binding to estrogen response elements sites on the oct4 gene in human breast cancer stem cells
PMID: 37280194 17
More specifically, the study posits that Epithalon may alter chromatin structure by specifically interacting with histones, thereby modulating gene expression
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