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The 2025 review also reported that in a large retrospective study of 461,328 adults initiating GLP-1 therapy, over 22% developed at least one nutritional deficiency within 12 months, with vitamin D the most common deficiency identified
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S.SalemV.et al
When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur
Participants were divided into those receiving concurrent hormone therapy and those who were not, with groups carefully matched by age, BMI, and clinical history to reduce the most obvious confounding variables
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