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and (5) HG + SB431542 (10 M)

The potential cost of skewed data far outweighs the cost of reconstituting a fresh vial

This platform co-delivered VEGF-targeting siRNA, ultrasmall superparamagnetic iron oxide NPs (USPIOs), and the chemotherapeutic agent SN-38

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3.5 Overall phase I metabolism in cirrhosis is robust despite the downregulation of pericentral CYPs As summarized previously, a strong decrease in the expression of phase I metabolizing enzymes in cirrhotic compared to control livers was observed (Figure 1B), in particular CYPs, which are expressed in the pericentral region of the liver lobule