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Taken together, the flux-constraint perspective reframes GLP-1RA therapy as a systemic metabolic state in which therapeutic durability depends on maintaining proportionality between oxidative throughput and substrate-supported regenerative capacity
Chen YI, Wei PC, Hsu JL, Su FY, Lee WH
GLP-1 binds to GLP-1 receptor (GLP-1R), a G-protein coupled receptor present in several tissues throughout the body